Scientists Create Mice With Two Fathers and No Mother: 'Revolutionary'
new study published in the journal Nature how they successfully changed male cells into eggs.The researchers hope that their findings may pave the way for this technology's use in humans, allowing male couples to have biological children without using a female egg donor.In the past, scientists have created mice with two biological fathers using genetic engineering and several complex steps using embryonic cells.
They have also previously transformed female mouse body cells into eggs. This, however, marks the first time that viable eggs have been grown from male cells.In the study, the scientists described how they took skin cells from a male's tail and cultured them in a petri dish to become pluripotent stem cells, which can grow to become any other cell type.Like humans, male mice cells contain one X and one Y chromosome, while female cells contain two X chromosomes.
During the culturing to become stem cells, roughly 6 percent of the mice cells lost their Y chromosome, leaving them as XO. The scientists then used a drug called reversine and a fluorescent protein to duplicate the existing X chromosomes, making the cells XX.Next, the scientists manipulated the XX cells to grow into egg cells, which were then fertilized with the sperm of another male and implanted into a female mouse surrogate.Seven pups were born after 630 attempts, meaning that the success rate was around 1 percent.
However, the pups themselves appear healthy and themselves are fertile, but will need to carefully study to investigate all and any ways in which they differ from those bred with a father and a mother.This is a "revolutionary paper", Nitzan Gonen, the head of the sex determination laboratory at Israel's Bar-Ilan University, told AFP."This.
